Patients undergo complex pathophysiological changes after injury. In severe cases, life-threatening conditions such as shock or sepsis can occur.

Trauma Care Consult has 20 years of experience in examining the underlying mechanisms of post-traumatic complications to provide the earliest diagnosis and well-tailored therapies for every single case.

Shock

Hypovolemic shock due to hemorrhages is a common cause of microcirculatory disturbances and oxygenation deficiency in trauma patients. It can ultimately lead to systemic inflammatory response syndrome, multi-organ failure and death of the patient. To provide new therapeutic approaches, T.C.C. is examining the underlying mechanisms of post-traumatic complications.

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Sepsis

One out of four sepsis patients dies despite adequate treatment. The diverse causes make the disease difficult to diagnose and even harder to treat. As time is crucial for the chance of survival, T.C.C. is developing methods of prediction and early diagnosis.

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Trauma-induced Coagulopathy

Trauma patients suffering from severe bleeding are of high risk to develop a disturbance of blood coagulation, which further worsens their condition. A specific administration of medication and clotting factors at the right time is crucial. Research at T.C.C. is putting a special emphasis on enabling quick diagnosis of clotting disturbances and their appropriate treatment for a personalized therapy approach.

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Molecular Mechanisms of Organ Failure

Understanding the underlying molecular mechanisms of trauma-, shock- and inflammation-induced organ failure is essential to developing new diagnostic methods and therapeutic targets. T.C.C. is looking into the dysfunction of different intracellular structures and examines pathological changes of intracellular signaling cascades.

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Monitoring

A quick and reliable diagnosis of posttraumatic complications is one of the greatest challenges for the management of trauma patients. To optimize the clinical decision-making process, T.C.C. is working on the improvement of diagnostic measures and the characterization of potential pathophysiological risk factors.

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